Suzhou Haiyu Biochem Industrial Co.,Ltd.

Home Home Contact us Contact us China 中文版
Products Search
Contact us
Suzhou Haiyu Biochem Industrial Co.,Ltd.
Contact: Jason Li
Tel: 0512-68097639
Mobile: 18013585858
Email: sales@haiyubiochem.com,haiyubiochem@qq.com
Address: #6,Jinshan Road ,Suzhou New District,Jiangsu,P.R.China
Current position: Home >Data > R 58 735: A new antihypoxic drug with anticonvulsant properties and possible effects on cognitive functions
Data

R 58 735: A new antihypoxic drug with anticonvulsant properties and possible effects on cognitive functions

Drug Development Research  2012/6/20 2:04:57

R 58 735, a benzthiazole derivative, is a potent antihypoxic agent with anticonvulsant properties. As an antihypoxic drug, it was more potent than any other reference substance in hypobaric hypoxia in mice and in histotoxic dysoxia and nitrogen hypoxia in rats. In the nitrogen hypoxia test, R 58 735 was equipotent in males and females, and the p.o.\i.v. ratio varied from 2.8 to 2.6. The antihypoxic activity of orally administered R 58 735 latested more than 8, but less than 24 hr. The anticonvulsant profile of R 58 735 resembled that of flunarizine, i.e., blockade of the tonic convulsions induced by pentylenetetrazol, allylglycine, or bicuculline, but not of clonic convulsions, except those seen in audiogenic seizureprone mice. In the allylglycine or bicuculline tests, it was more potent than any other reference anticonvulsant. In the bicuculline test, there were no sex-related differences in activity, and the p.o.\s.c. activity ratio was 2.01 in males and 1.74 in females. Following oral administration, the duration of anticonvulsant activity in the bicuculline test was more than 8, but less than 24 hr. In guinea pigs, R 58 735 completely antagonized hypoxia-induced amnesia at a dose of 2.5 mg\kg s.c. Furthermore, it enhanced acquisition of a two-way avoidance task over a broad dose range (0.63–20 mg\kg) in rats. 

Drug Development Research

Volume 8, Issue 1-4, pages 373–380, May - August 1986 

 Online Advisory
点击这里给我发消息
 Telephone
0512-68097639

MSN:dikarmun@hotmail.com 
Back Home
Contact us